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KMID : 0603520030080020091
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Journal of Korean Association of Cancer Prevention
2003 Volume.8 No. 2 p.91 ~ p.97
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Chemopreventive Effect of Xanthorrhizol from Curcuma xanthorrhiza
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Park Jae-Hee
Kim Mi-Jeong
Park Kwang-Kyun
Kim Heui-Og
Hwang Jae-Kwan
Chung Won-Yoon
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Abstract
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Xanthorrhizol is a sesquiterpenoid isolated from Curcuma xanthorrhiza that has been known to possess anti-inflammatory and anti-carcinogenic effects. In this work, we have found that xanthorrhizol reduced superoxide anion generation by 12-O-tetradecanoylphorbol- 13-acetate (TPA) in differentiated HL-60 cells and exerted a dose-related inhibition of His+ reversion in Salmonella typhimurium TA102 induced by tert-butylhydroperoxide (t-BOOH) and hydrogen peroxide. Pretreatment of xanthorrhizol significantly decreased the incidence and the multiplicity of mouse skin tumors stimulated by TPA for 19 weeks after a single application of dimethylbenz[a]anthracene (DMBA), and mitigated the expression of epidermal ornithine decarboxylase in the skins. These results demonstrate that xanthorrhizol may be a potent cancer chemopreventive agent.
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KEYWORD
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Curcuma xanthorrhiza, Xanthorrhizol, Chemopreventive agent
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